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Literature Review

Just want the facts?

Here’s a list of notable information about Barrett’s Esophagus and Gastroesophageal Reflux Disease (GERD).

  • Barrett’s Esophagus is a complication of Gastroesophageal Reflux Disease (GERD).
  • Barrett’s Esophagus is considered a precursor to esophageal adenocarcinoma.
  • GERD affects an estimated 25%-35% of the US population (7%-10% with daily symptoms).
  • 10%-20% of patients with chronic GERD symptoms have Barrett’s Esophagus.
  • 44% of Barrett’s patients lack consistent severe GERD symptoms.
  • Barrett’s Esophagus patients have 30-125 times greater risk of developing esophageal cancer.
  • The incidence of esophageal adenocarcinoma is rising more rapidly than any other cancer, six fold increase from 1975 to 2001.
  • The prevalence of Barrett’s Esophagus in general population is 1.6%, approximately 3.3 million in the United States.
  • In an endoscopic series of patients, 0.9%-4.5% had Barrett’s Esophagus. The prevalence of Cancer, High Grade Dysplasia, and Low Grade Dysplasia in Barrett’s Esophagus are 6.7%, 3.0%, and 7.3%, respectively.
  • The incidence rate of Cancer, High Grade Dysplasia, and Low Grade Dysplasia in Barrett’s Esophagus are 0.5%, 0.9% and 4.3% per year, respectively.
  • 5% of patients with Barrett’s Esophagus develop esophageal cancer within 5-8 years of diagnosis.
  • The incidence of High Grade Dysplasia progressing to cancer is 10% (range 6%-19%) per year.
  • The incidence of Low Grade Dysplasia progressing to cancer is 0.6% per year.
  • 53% of patients with Cancer/High Grade Dysplasia have no dysplasia at their 1st two scopes.
  • Short segment Barrett’s (≤ 3 cm) is 3 times more common than long segment Barrett’s Esophagus.
  • Genetic variation in two chromosomes have been linked to development of Barrett’s Esophagus.
  • Risk of mortality from esophagectomy for Barrett’s Esophagus is 2% (range of 0-4%).
  • 5-year survival rate for late stage esophageal adenocarcinoma is approximately 13%.