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Clinical Trials

Clinical trials are research studies designed to discover new ways to treat different cancers, and directly impact the number of new therapies and treatments available to fight cancer. Today’s trials are tomorrow’s standard of cancer care.

Thompson was the first to bring cancer clinical trials to East Tennessee more than 25 years ago. Our oncologists are certified to participate in clinical trials and work with multiple cancer research groups to bring innovative treatments to East Tennessee. In addition, we partner with pharmaceutical companies to give our patients access to new treatments not otherwise available. We offer clinical trials because they often lead to better ways to diagnose, treat, and prevent cancer, allowing people to live healthier and longer lives. Ask your doctor if a clinical trial might be right for you.


Protocol Number NCT Number Summary Principal Investigator
NSABP  B-51/RTOG 1304 NCT01872975 A study for women with early stage breast cancer to determine if giving less radiation is as effective as traditional radiation in patients who have had a very good response to chemotherapy received prior to surgery. Grant Clark, MD
S1418/BR006 NCT02954874 For patients with high risk “triple negative” breast cancer, a study to see if using an immunotherapy (Pembrolizumab) after the usual treatments will help keep breast cancer from returning. Jashmin Patel, MD


Protocol Number NCT Number Summary Principal Investigator
A021502 NCT02912559 For patients with stage III colon cancer with deficient mismatch repair, to see if adding an immunotherapy (Atezolizumab) to the usual chemotherapy given after surgery will decrease the chance of cancer returning.   Jashmin Patel, MD


Protocol Number NCT Number Summary Principal Investigator
NRG-GU005 NCT03367702 For patients with localized intermediate risk prostate cancer, testing short course radiation therapy versus standard radiotherapy. Grant Clark, MD


Protocol Number NCT Number Summary Principal Investigator
NRG-GY005 NCT02502266 For patients with recurrent platinum resistant or refractory ovarian, fallopian tube, or primary peritoneal cancer, to test the combination of cediranib and olaparib in comparison to each drug alone or other chemotherapy. Brook Saunders, MD


Protocol Number NCT Number Summary Principal Investigator
AZA-MDS-006 (CONNECT) n/a For patients with new Leukemia and MDS, this study is gathering information about how patients feel when being treated for this cancer, what kind of medicine they are taking, and how their medicine is affecting them.  Jashmin Patel, MD 

Lung: Small Cell

Protocol Number NCT Number Summary Principal Investigator
CALGB 30610 NCT00632853 A study for limited stage small cell lung cancer to compare two different ways to give radiation therapy to see which is more effective. In addition, every patient will get chemotherapy with Cisplatin and Etoposide, which is standard treatment for this type of lung cancer. Grant Clark, MD
NRG-CC003 NCT02635009 For patients with small cell lung cancer (limited and extensive stage), to test whether avoiding the hippocampus (part of the brain that is important for memory) during whole-brain radiation therapy prevents cognitive side effects. Grant Clark, MD
NRG-LU005 NCT03811002 For patients with limited stage small cell lung cancer, to test usual chemoradiation therapy, versus chemoradiation therapy plus the addition of a new immunotherapy drug, Atezolzumab (MPDL3280A). Grant Clark, MD


Protocol Number NCT Number Summary Principal Investigator
NCT02224781 A study to determine which is the best sequence (targeted therapy followed by immunotherapy, or immunotherapy followed by targeted therapy) for treating patients with advanced BRAF positive melanoma. The medications include: Dabrafenib, Trametinib, Ipilimumab, and Nivolumab. Jashmin Patel, MD


Recurrent Tumors, Lymphomas, and Multiple Myeloma

Protocol Number NCT Number Summary Principal Investigator
EAY 131 MATCH NCT02465060 A study to test more than 25 different treatments for patients with recurrent or rare cancers with a molecular profile that “matches” a targeted therapy. Brook Saunders, MD